Retinoic Acid
Notable concerns
INCI · Retinoic AcidCAS 302-79-4
Also known as: Tretinoin · all-trans-Retinoic Acid
ConditioningExfoliant
In plain language
The purest, fully active form of Vitamin A (usually available by prescription only) that binds directly to cell receptors to treat acne and severe photoaging.
The FDA-approved gold standard for clearing comedonal acne and reversing signs of aging.
Can cause significant initial irritation, peeling (the 'retinization' process), and sun sensitivity. Strictly contraindicated during pregnancy.
Benefits
Benefit
Photoaging Reversal
Tretinoin is widely considered the most effective topical therapy for clinical improvement in fine wrinkling and mottled hyperpigmentation.
Strong evidence
Where it can be sold
Simplified regulatory status by market — for guidance, not compliance advice.
European UnionRestricted
Banned in cosmetic products (Annex II); available only as a prescription medicinal product.
01
Topical tretinoin for photoaged skin: a double-blind vehicle-controlled study ↗
JAMA · 1988
Peer-reviewed